Title: Principles of health based assessment of chemical substances with respect to the setting of quality criteria for air, soil and water 
Resource Type: document --> technical publication --> report 
Country: Denmark 
Language(s): Danish
English
 
Year: 2004 
Availability: Environmental project, Miljørapport nr. 974 
Author 1/Producer: Nielsen, Elsa 
Other Authors/Producers: Østergaard, Grete; Larsen, John Christian; Ladefoged, O. 
Author / Producer Type: Agency, regulator or other governmental or inter-governmental body 
Publisher: The Danish Environmental Protection Agency, Miljøstyrelsen 
Publisher City: Strandgade 29, DK-1405 Copenhagen K, Denmark 
ISBN: 87-7614-488-7 
Report / download web link (=direct link): http://www2.mst.dk/common/Udgivramme/Frame.asp?pg=http://www ...  
Format (e.g. PDF): PDF 
Size: (e.g. 20mb) 700 
EUGRIS Keyword(s): Contaminated land-->policy and regulatory
 
Short description: The objective is to review the newest developments in risk assessment of chemical substances and incorporate vital aspects in a new guideline on the principles for the setting of health based quality criteria in soil, drinking water and ambient air, but with due regard for the principles previously in force. 
Long description: The scientific basis for the assessment of health based quality criteria for chemical substances in soil, drinking water and ambient air consists of a hazard identification, a dose – response assessment (hazard characterisation), and an exposure assessment. The most critical effect is identified and can either be a threshold effect or an effect which gives some risk at any level (non-threshold, e.g. genotoxic carcinogens). The threshold effect allows the derivation of the tolerable daily intake (TDI) by dividing the NOAEL (or LOAEL) with uncertainty factors; UFI, UFII and UFIII. UFI accounts for the interspecies variation (max. 10), UFII accounts for the differences in inter-individual susceptibility (max 10) and UFIII accounts for the quality and relevance of the data (max 100). For non-threshold effects, the One-hit model or alternatively, the T25-approach are recommended and a lifetime risk of 10-6 is applied. 
Submitted By: Dr Jacqueline Falkenberg WhoDoesWhat?      Last update: 31/01/2007