Title: CPDW project – Assessment of cytotoxicological potential of products in contact with drinking water 
Resource Type: document --> technical publication --> report 
Country: EU Projects 
Year: 2004 
Availability: Enkiri, F. et al. (2004) CPDW project – Assessment of cytotoxicological potential of products in contact with drinking water. EC Report EUR 21397/1 EN 2004 
Author 1/Producer: Enkiri, F. 
Other Authors/Producers: Colle, D., T. Grummt, T., Matthews, C., Marcos, R., Westphal, H., Hoekstra, E.J., Philippe, M., Neveu, P. 
Author / Producer Type: EC Project 
Publisher: JRC 
Publisher City: Document is downloadable from the JRC web site, but a direct link cannot be provided, so download via the search function 
Report / download web link (=direct link): http://www.jrc.cec.eu.int  
Format (e.g. PDF): PDF 
EUGRIS Keyword(s): Contaminated land-->Risk assessment-->Receptor: Water
Groundwater protection-->Groundwater protection overview
Water resources and their management -->Water resources and their management Overview
Short description: Development of a harmonised test to be used in the European Acceptance Scheme concerning CPDW 
Long description: This is a draft report of the WP on cytotoxicity and genotoxicity. It is a compilation of the results and put together by the scientific co-ordinator. The WP is still working on reporting the results in scientific and toxicological way. However, the conclusions and recommendations will not change drastically. For the purpose of the Regulators and the progress of the EAS this draft report was prepared. It is of public interest that consumers are not exposed to toxic chemicals. Materials in contact with drinking water may release toxic chemicals and therefore these materials have to be approved for their purpose. Chemicals known from the formulation of the material will need a toxicological evaluation before it can be used in a material covered by the EAS. However, materials may also contain impurities and reaction products, which will not or cannot be assessed toxicologically and/or which are not covered in any other assessment in the EAS. In addition the toxic effect of a mixture of chemicals can be different compared to the “sum of effects” of the individual chemicals of that mixture. Many comparisons have already shown there is no correlation between organic compounds detected by physical and chemical analysis and cytotoxic compounds: substances, which are detected by GC-MS, are not necessarily toxic and obviously cytotoxic compounds are not always detected by physical and chemical analysis. Although chemical analysis is necessary, it is not sufficient and therefore a toxicological evaluation is also necessary: these two methods are complementary. So there is a need for rapid and reliable tests that detect toxic effects of chemicals released by materials in contact with drinking water. Such test or test battery may be well fitted at the end of the acceptance process of a material. It will be the final check on the suitability of a material in contact with drinking water. The application of the test or test battery requires a statistically robust design with reproducible and unambiguous test results in order to treat all materials equally under regulation. The current French Cytotoxicity Test (FCT) used in the French acceptance scheme was considered as the most appropriate test for the EAS due to its objective endpoint. This test is harmonised in this report. Cytotoxicity tests only measure the potential metabolic effect of the compounds released by the materials, and do not allow conclusions to be drawn about the potential mutagenetic effects of those. Risks of the genome damages by molecules which are present in tap water or which are released by CPDW can be considered as insignificant, this is why a genotoxicity test should go alongside the cytotoxicity one. The objectives of the work are: • to make a review of the cytotoxicity tests applied to the water distribution systems in European countries to fix variables for future tests, and a review of the available genotoxicity tests to determine if one of them could be appropriate • to carry out a realistic test of cytotoxicity with a range of organic, cementitious and metallic materials • to validate the results statistically • to propose a validated procedure to test the cytotoxicity of leachates from CPDW which can serve as a basis for a harmonised CEN standard and to provide acceptance criteria for the EAS. 4 WP2 participants are still discussing the presentation and interpretation of the results. This part of the report is the interpretation of the results by the scientific co-ordinator. It should be considered as draft and may be due to changes. As for all other WPs a detailed separate final report will be presented. 
Link to Project(s): CPDW Development of harmonised tests to be used in the European Approval Scheme concerning Construction Products in contact with Drinking Water
Link to Organisation(s): JRC Joint Research Centre ISPRA
Submitted By: Dr Stefan Gödeke WhoDoesWhat?      Last update: 10/10/2006

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