Title: In vitro modulations of estrogenic responce by polychlorinated biphenyls 
Resource Type: document --> technical publication --> proceedings / conference paper(s) 
Country: EU Projects 
Year of publication: 2003 
Availability: Plíšková, M. et al. (2003) In vitro modulations of estrogenic responce by polychlorinated biphenyls. Persistent Toxic Substances Contamination of the European Region as a reflection of results of the GEF/UNEP Regional Based Assessment of Persistent Toxic Substances (RBA PTS) in Europe, the implementation of the Stockholm Convention and 'Community Strategy for Dioxins, Furans and PCBs 
Author 1/Producer: Plíšková, M. 
Other Authors/Producers: Neèa, J., Sovadinová, I., Bláha, L., Vondráèek, J., Machala, M. 
Author / Producer Type: EC Project 
Report / download web link (=direct link): http://www.recetox.muni.cz/coe/sources/workshop_1_rba_pts/VI ...  
EUGRIS Keyword(s): Diffuse pollution-->Diffuse pollution overview
Short description: Although the environmental levels of polychlorinated biphenyls (PCBs) are decreasing as a result of their banning, bioaccumulation can still lead to significant levels found in humans and animals. Endocrine disruption by PCBs has been studied intensively both in vitro and in vivo, as one of their potential toxic modes of action. Early studies have indicated a weak estrogenic activity of PCB mixtures, suggesting that lower-chlorinated hydroxy-PCB metabolites are the active compounds (Nelson, 1974). On the other hand, anti-estrogenic actions of hydroxy-PCBs acting as estrogen receptors (ERs) antagonists have been reported as well (Kramer et al., 1997). A number of non-ortho-chlorinated PCBs, known as aryl hydrocarbon receptor (AhR) agonists, might also interfere with estrogenic activity (Zacharewski et al., 1991; Krishnan and Safe, 1993). However, the activities of either PCB congeners or their metabolites reported in a number of previous studies were variable and depended on the selected cellular system. Only a few systematic studies of estrogenicity/antiestrogenicity of PCBs have been reported. In this study, antiestrogenic and estrogenic activities of indicator PCB congeners and hydroxy-PCB metabolites were determined using the ER-CALUX assay. In a second step, we examined potential estrogenic and anti-estrogenic activities in both crude and sulfuric acid-silica fractionated extracts of male human serum samples from a Slovak region highly contaminated by PCBs, and from a control region with low level of PCB contamination. 
Link to Project(s): RECETOX Centre of Excellence in Environmental Chemistry and Ecotoxicology
Submitted By: Dr Stefan Gödeke WhoDoesWhat?      Last update: 14/02/2006

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