| Title: |
Simultaneous determination of selected endocrine disrupters (pesticides, phenols and phthalates) in water by in-field solid-phaseextraction (SPE) using the prototype PROFEXS followed by on-line SPE (PROSPEKT) and analysis by liquid chromatography-atmospheric pressure chemical ionisation-mass spectrometry
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| Resource Type: |
document --> technical publication --> journal article
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| Country: |
EU Projects
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| Year: |
2004 |
| Availability: |
López-Roldán, P. et al. (2004) Simultaneous determination of selected endocrine disrupters (pesticides, phenols and phthalates) in water by in-field solid-phaseextraction (SPE) using the prototype PROFEXS followed by on-line SPE (PROSPEKT) and analysis by liquid chromatography-atmospheric pressure chemical ionisation-mass spectrometry. Anal Bioanal Chem (2004) 378 : 599–609
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| Author 1/Producer: |
López-Roldán, P.
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| Other Authors/Producers: |
López de Alda, M. J., ·Barceló, D.
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| Author / Producer Type: |
EC Project
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| Format (e.g. PDF): |
PDF
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EUGRIS Keyword(s): |
Contaminated land-->Contaminants-->Contaminants overview
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| Short description: |
In this study, a new procedure, based on on-line
solid-phase extraction (SPE) and analysis by liquid-chromatography-
atmospheric pressure chemical ionizationmass
spectrometry (LC-APCI-MS), has been developed
for the simultaneous, multianalyte determination of 21 selected
pesticides, phenols and phthalates in water. SPE was
carried out on polymeric PLRP-s cartridges by percolating
20 mL-samples. For sample preconcentration, the performance
of a prototype programmable field extraction
system (PROFEXS) was evaluated against the commercial
laboratory bench Prospekt system used for method development.
The Profexs is designed for the automated on-site
sampling, SPE preconcentration, and storage of up to 16
samples in SPE cartridges. These cartridges are further
eluted and on-line analyzed with the Prospekt coupled to
the chromatographic system. In the optimized method,
where completely on-line SPE-LC-MS analysis of the samples
is carried out with the Prospekt in the laboratory, detection
limits lower than 100 ng/L, and satisfactory precision
(relative standard deviations <25%) and accuracies
(recovery percentages >75%) were obtained for most investigated
compounds from the analysis of spiked Milli-Q
water. The extraction efficiency achieved with the Profexs
was comparable to that of the Prospekt for most compounds
and somewhat lower for the most apolar analytes, probably
due to adsorption on the pump filters. The completely
on-line optimized method was applied to the analysis of
surface water, ground water and drinking water from a
waterworks in Barcelona. Some pesticides and phenols
were found in both surface water and groundwater at ng/L
or µg/L levels, but not in the final drinking water. Di(2-ethylhexyl)
phthalate (DEHP) was present in all samples investigated,
including blanks. To the author’s knowledge,
this is the first work describing the application of a fully
automated on-line SPE-LC-MS method for the simultaneous
analysis of pesticides, phenols, and phthalates in water,
and the second one that examines the possibilities of the
prototype Profexs for automated on-site SPE preconcentration
of organic pollutants from water samples.
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Submitted By:
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Dr Stefan Gödeke WhoDoesWhat?
Last update: 14/02/2006
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