Title: First evidence of endocrine disruption in feral carp from the Ebro River. 
Resource Type: document --> technical publication --> journal article 
Country: EU Projects 
Year: 2004 
Availability: Lavado R, Thibaut R, Raldua D, Martin R, Porte C (2004): First evidence of endocrine disruption in feral carp from the Ebro River. Toxicol. Appl. Pharmacol. 196, 247-257 
Author 1/Producer: Lavado R. 
Other Authors/Producers: Thibaut R, Raldua D, Martin R, Porte C 
Author / Producer Type: EC Project 
Article Weblink (=direct link): http://www.comprendo-project.org/_files/TAAP2004carps.pdf  
Format (e.g. PDF): PDF 
EUGRIS Keyword(s): Contaminated land-->Contaminants-->Contaminants overview
Short description: Feral carps (Cyprinus carpio) were collected in spring 2001 from five sites along the lower course of Ebro River (Spain) with the aim of investigating the existence of endocrine-disrupting effects. Several findings (low gonadosomatic index (GSI), plasmatic vitellogenin (VTG), depressed levels of testosterone, and histological alterations in gonads) detected in male carps downstream of Zaragoza’s sewage treatment plant (STP) strongly suggest that the concentration of sewage effluent in the area is a major causal factor leading to the detected estrogenic effects. Important alterations (viz. delayed maturation in females, indications of arrested spermatogenesis in males) were detected in carps from Flix, a heavily industrialized area. Low ovarian P-450 aromatase and reduced glucuronidation of testosterone and estradiol in males were observed in Zaragoza and Canal Imperial de Arago´n—an agricultural area—which suggest decreased estrogen synthesis, and possibly, reduced sex hormone excretion in those organisms. These results were related to some in vitro assays aimed to assess the interference of model compounds (atrazin, vinclozolin, diuron, pp’-DDE, dicofol, triphenyltin, nonylphenol, and fenarimol) with the glucuronidation of testosterone and estradiol by liver microsomal fractions. The fungicide fenarimol (10–20 AM) and nonylphenol (50 AM) were found to significantly inhibit (20%) both activities at relatively low doses. Overall, this work provides the first evidence of the existence of significant alterations of the endocrine system of carps from the medium-low course of the Ebro River and demonstrates the ability of several chemicals to modulate the inactivation of endogenous steroids. 
Link to Project(s): COMPRENDO Comparative Research on Endocrine Disrupters - Phylogenetic Approach and Common Principles focussing on Androgenic/Antiandrogenic Compounds
Submitted By: Dr Stefan Gödeke WhoDoesWhat?      Last update: 14/02/2006