EURISKED Multi-organic risk assessment of selected endocrine disrupters (ED's)

Country: EU Projects
Start Date:   30/9/2002         Duration: 36 months         Project Type: RTD
Contract Number: EVK1-CT-2002-00128
Organisation Type:  EC Project
Topics: 
Contaminated land-->Contaminants-->Others
Contaminated land-->Risk assessment-->Toxicological information
Project objectives:
Ultimate goal of the EURISKED project is to determine multi-organic effects of a variety of endocrine disrupters (EDs) and these are: OMC, Nonylphenol, 4-MBC, 
Bisphenol A, Dibutylphtalate, Benzophenone-2, Procymidon Linuron, Resveratrol, 8-prenylnaringenin, genistein, estradiol-benzoat, androstandiol.
The plant derived substances and the plasticisers have been shown to be uterotropic, i.e. to have estrogenic effect in the uterus, while the 2 pesticides prevented
androgen stimulated prostate growth. Since these steroids, but also thyroid hormones and glucocorticoids have profound effects in many other organs outside
the reproductive tract it is a goal of this project to study these effect outside the reproductive tract. As a control, targets within the reproductive tract
need to be incorporated in the study design as well.
Project Summary:
ED's with steroidal or anti-steroidal effects may be of great importance during embryonic development and later for metabolic, brain, cardiovascular, reproductive, 
and bone function. The effects of UV-absorbing chemicals (4-MDC, homosalate), characterised recently as estrogenic, and of Benzophenone D, a chemical used
in cosmetics, as well as the fungicide Procymidone and the pesticide Linuron will be studied in rats and gene-targeted mice. High throughput methods to identify
ED's with (anti) estrogenic (anti) androgenic, (anti) progestational, (anti) glucocorticoid, and (anti) thyroid hormone activities will be employed.
Gene-targeted cell lines and animals, including the EU-sponsored EUROSTERONE DNA chip, will seek to quantify both ED's and their effects on gene and protein
expression in different organs. This will lead to clear concepts for clinical trials towards the end of the project.
Achieved Objectives:

            
Product Descriptions:

            
Additional Information:

            
Project Resources:

Effect of oral intake of dibutyl phthalate on reproductive parameters of Long Evans rats and pre-pubertal development of their offspring

Human thyroid carcinoma cell lines show different retinoid receptor repertoires and retinoid responses

Endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney

Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of Nonthyroidal Illness mainly via the central part of the hypothalamus-pituitary-thyroid axis

Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphtalate (DBP)in uterus, vagina and bone

Multi-organic endocrine disrupting activity of the UV screen benzophenone 2 (BP2) in ovariectomized adult rats after 5 days treatment

Effects of estradiol, benzophenone-2 and benzophenone-3 on the expression pattern of the estrogen receptors (ER) alpha and beta, the estrogen receptor-related receptor 1 (ERR1) and the aryl hydrocarbon receptor (AhR) in adult ovariectomized rats

Anti-inflammatory and proliferative responses in human and ovine ovarian surface epithelial cells

Estrogenic activity and estrogen receptor b binding of the UV filter 3-benzylidene camphor. Comparison with 4-methylbenzylidene camphor

Endocrine activity and developmental toxicity of cosmetic UV filters - an update

Effects of 5-day styrene inhalation on serum LH and testosterone levels and on hypothalamic and striatal aminoacid neurotransmitter concentrations in male rats

Screening of some anti-androgenic endocrine disruptors using a recombinant cell-based in vitro bioassay

Contribution of Interleukin-12 to the pathogenesis of nonthyroidal illness

Evidence for SERM activity in a Black Cohosh (Cimicifuga racemosa) extract: Comparison with estradiol-17

UV filters with antagonistic action at androgen receptors in the MDA-kb2 cell transcriptional-activation assay

Sex- and region-specific alterations of progesterone receptor mRNA levels and estrogen sensitivity in rat brain following developmental exposure to the estrogenic UV filter 4-methylbenzylidene camphor INA-9

Phytoestrogens: Endocrine disrupters or replacement for hormone replacement therapy?

Thyroid hormone receptors and type I iodothyronine 5-deiodinase activity of human thyroid toxic adenomas and benign cold nodules

The promoter of the human sodium/iodide-symporter gene responds to retinoic acid

Expression and regulation of telomerase genes in thyroid carcinoma

Expression of 5-deiodinase enzymes in normal pituitaries and various human pituitary adenomas

Clinical impact of retinoids in redifferentiation therapy of advanced Thyroid cancer final results of a Pilot study

Iododthyronine Deiodinases In: Methods in Enzymology

The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health
Weblink:
http://www.eurisked.org/
Funding Programme(s): 
EC Framework Programme 5
Link to Organisations:
Submitted by: EUGRIS Team Prof Paul Bardos  Who does what?  03/07/2003 17:48:00
Updated by: EUGRIS Team Professor Paul Bardos  Who does what?  03/10/2006 11:39:00