| Project objectives:
The aim of the project is to consider joint effects of toxicants in risk assessment procedures and regulatory measures for the protection of aquatic life.
The specific objectives of BEAM were:
• To achieve more environmental realism in the scientific hazard assessment of complex exposure situations by addressing the following questions:
- what are realistic exposure scenarios with respect to mixtures,
- how relevant are combination effects due to mixtures that are typically found in the environment, and
- may the toxicity of such mixtures be predictable from single substances toxicity data?
The project wanted to provide three new instruments for the assessment of mixture toxicity:
- a swift biotest suitable for analysing effects of mixtures of pollutants on natural biological communities at ecological time scales,
- a chemometric/QSAR methodology for grouping toxicants with unknown modes of action according to the predictive concepts of Concentration Addition and
Independent Action, and
- a framework of biometrical demands for the design of mixture toxicity experiments and the predictive assessment of mixture toxicity in terms of data quality
- to explore the options for implementation of predictive mixture toxicity assessment into regulation by:
- compiling and reviewing existing approaches,
- developing decision rules for the applicability of the concepts of Concentration Addition and Independent Action,
- defining a framework for the risk assessment of mixtures of aquatic pollutants,
- developing protocols for the classification of ecological water quality in relation to mixture fate and effects.
| Product Descriptions:
The available publications are:
T. Backhaus, R. Altenburger, Å. Arrhenius, H. Blanck, F. Consolaro, M. Faust, A. Finizio, P. Gramatica, F. Grönvall, M. Scholze, M. Vighi, H. Walter, L. H.
Grimme: Bridging the Gap between Science and Regulation of Chemical Mixtures: The 'BEAM' EU Research Project, Poster Presentation at the 3rd SETAC World Congress,
Brighton, UK, 2000
L. Horst Grimme, Rolf Altenburger, Åsa Arrhenius, Thomas Backhaus, Hans Blanck, Federica Consolaro, Michael Faust, Antonio Finizio, Paola Gramatica,
Matthias Grothe, Marion Junghans, Manuela Pavan, Martin Scholze, Roberto Todeschini, Marco Vighi, Sara Villa, Helge Walter: Risk Assessment of Chemical
Mixtures in the Aquatic Environment: An Outline of the BEAM Project EurOcean - 2000; The European Conference on Marine Science and Ocean Technology, Hamburg,
Germany; Book of Project Synopses, Vol 1: 'Marine Processes, Ecosystems and Interactions', page 219-224, 2000