Short description and topics:
EXTRACT: Bioavailability issues surrounding metal-contaminated soils and media have been an
area of intense research. For obvious ethical reasons, we cannot solicit humans, in particular
the sensitive population of children, from the general population for experimental purposes to
examine the long-term harmful effect of metals in soils. However, some adult human feeding studies
have been accomplished under tight medical supervision and with very small doses. One option to
understand and relate bioavailability in humans is to employ animal surrogates; however, the physiology
of most animals is different than that of humans but good correlations have been achieved despite
the dose–response paradigm not being identical.
Contaminated land-->Contaminants-->Heavy metals
Contaminated land-->Risk assessment-->Toxicological information
Diffuse pollution-->Processes
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